Multiple Myeloma Update — Part 2: Our interview with Dr
Richardson highlights the following topics as well as cases from
his practice:
Approach to treatment decision-making for patients with newly
diagnosed MM; strategic use of transplant and evolution of
treatment modalities (00:00)
Case: A woman in her early 70s presents with
lambda light chain MM and widespread lytic bone disease
(06:15)
Consideration of daratumumab as a component of induction
therapy (08:55)
Comparison of the efficacy, tolerability and dosing of
bortezomib and ixazomib in the up-front setting (11:38)
Activity and tolerability of melflufen in combination with
dexamethasone in patients with R/R MM refractory to pomalidomide
and/or daratumumab (13:16)
Novel mechanism of action of melflufen; synergistic activity in
combination with dexamethasone and either bortezomib or daratumumab
on the ANCHOR trial (17:41)
Clinical experience with melflufen-associated cytopenias
(23:48)
Mechanism of action, activity, tolerability and recent FDA
approval of the XPO1 inhibitor selinexor in combination with
dexamethasone for multiagent-refractory MM (26:38)
Case: A man in his late 50s with R/R MM
receives anti-B-cell maturation antigen (BCMA) chimeric antigen
receptor (CAR) T-cell therapy on a clinical trial (34:22)
Therapeutic options after disease progression on anti-BCMA CAR
T-cell therapy (36:46)
Frequency and severity of toxicities, including cytokine
release syndrome, observed with various BCMA-directed CAR T-cell
platforms (38:02)
Case: A man in his early 60s with R/R MM with
the t(11;14) translocation elects to hold ASCT “in reserve” and
receives carfilzomib/venetoclax (42:12)
BELLINI trial: Perspective on outcomes for patients with and
without t(11;14) (45:01)
Featuring the video recorded proceedings of events held in conjunction with important scientific symposia, live webcasts and closed meetings featuring the perspectives of renowned clinical investigators, these videos provide an overview of important advances in the management of a number of solid tumors and hematologic cancers.