Breast Cancer Update for Surgeons, Issue 1, 2019 — Part #2: Our
interview with Dr King highlights the following topics as well as
cases from her practice:
Recent developments in the surgical care of patients with
breast cancer (00:0s
Predictive versus prognostic role of the 21-gene assay RS in
ER-positive, HER2-negative, node-positive breast cancer
(01:45)
Clinical implications of the TAILORx trial results (05:11)
Reliability of the 21-gene assay RS in guiding neoadjuvant
therapy decision-making (07:19)
Impact of genomic assay testing and clinical features on the
use of chemotherapy after the implementation of standardized reflex
testing criteria (10:39)
Clinical utility of the 21-gene assay RS in the selection of
therapy (15:34)
Application and utility of the MINDACT trial results; use of
the 70-gene signature assay in breast cancer (17:48)
Criteria for surgeon-initiated reflex gene-expression profile
testing for patients with early-stage breast cancer to reduce
delays in the initiation of chemotherapy (19:26)
Surgeon variability and factors predicting the need for
reoperation after breast-conserving surgery (24:22)
Recent trends in reoperation after initial lumpectomy for
patients with breast cancer (26:45)
Multidisciplinary management of the axilla for patients with
breast cancer undergoing primary mastectomy (28:25)
Optimal locoregional management of sentinel node-negative and
node-positive breast cancer (31:54)
Key issues regarding gross and microscopic evaluation of breast
and lymph node specimens after neoadjuvant systemic therapy
(36:36)
Importance of accurate specimen evaluation in assessing
treatment response (39:15)
Factors predicting the use of preoperative therapy for young
women with breast cancer; impact on breast-conserving surgery
(41:55)
Updated AJCC Staging Manual: Incorporation of tumor biology
into breast cancer staging to tailor treatment and refine prognosis
(43:46)
Case: A woman in her mid-40s with
ER/PR-negative, HER2-positive IDC receives neoadjuvant
paclitaxel/trastuzumab/pertuzumab on the Phase I DAPHNe trial
(47:22)
Perspective on the results of the KATHERINE trial (52:52)
Threshold for neoadjuvant therapy in triple-negative versus
HER2-positive breast cancer; side-effect profile of paclitaxel in
combination with trastuzumab and pertuzumab (54:51)
Case: A woman in her mid-30s with
triple-negative breast cancer has residual invasive disease in the
breast and axillary lymph nodes after receiving neoadjuvant
dose-dense AC followed by paclitaxel (56:49)
Perspective on the importance of genomic testing in guiding
treatment decision-making for patients with newly diagnosed disease
(1:01:7s
Surgical treatment options for patients with triple-negative
breast cancer and germline BRCA mutations (1:03:20)
Case: A woman in her mid-40s with
ER/PR-positive, HER2-negative IDC receives a RS of 18
(1:05:37)
Effects of age, menopausal status and RS on the prediction of
benefit from chemotherapy (1:08:14)
Featuring the video recorded proceedings of events held in conjunction with important scientific symposia, live webcasts and closed meetings featuring the perspectives of renowned clinical investigators, these videos provide an overview of important advances in the management of a number of solid tumors and hematologic cancers.