Feb 28, 2023

Featuring perspectives from Dr Mrinal Gounder, including the following topics:

•      Incidence and prevalence of desmoid tumors (00:00)

•      Outcomes associated with historical management paradigms for desmoid tumors (17:15)

•      Rationale for targeting the gamma secretase complex and Notch pathway as a therapeutic approach for desmoid tumors; mechanism of action of nirogacestat (20:56)

•      Key efficacy outcomes from the Phase III DeFi trial evaluating the gamma secretase inhibitor nirogacestat versus placebo for progressing desmoid tumors (30:14)

•      Spectrum and frequency of adverse events, including ovarian dysfunction, with nirogacestat (36:06)

CME information and select publications