Apr 7, 2026

Featuring an interview with Dr Ravin Ratan, including the following topics:

• Case: A woman in her early 40s who develops intense nausea and vomiting and is diagnosed with a pelvic desmoid tumor elects surveillance and experiences spontaneous regression of the tumor (0:00)
• Case: A woman in her late 30s with a painful...

Mar 16, 2026

Featuring an interview with Dr Ravin Ratan, including the following topics:

• Efficacy and safety of long-term continuous nirogacestat treatment in adults with desmoid tumors: Results from the Phase III DeFi trial (0:00)
• Onset and resolution of ovarian toxicity with nirogacestat treatment for desmoid tumors: Updated...

Jun 24, 2025

Featuring an interview with Dr Patrick Y Wen, including the following topics:

• Glioma classification (0:00)
• Efficacy and safety of vorasidenib in the management of IDH-mutant gliomas (4:50)
• Case: A woman in her early 30s with a Grade 2 astrocytoma and an IDH R132H mutation and residual disease...

Jun 23, 2025

Featuring a slide presentation and related discussion from Dr Patrick Y Wen, including the following topics:

• Classification and pathologic diagnosis of gliomas (0:00)
• Role of IDH inhibitors in the management of low-grade gliomas (6:37)
• Ongoing trials and remaining questions in the management of IDH-mutant gliomas...

Oct 18, 2024

Featuring perspectives from Dr Thierry Alcindor and Dr Mrinal Gounder, including the following topics:

• Introduction: Biology and Clinical Presentation (0:00)
• Case: A man in his mid 60s with desmoid fibromatosis — Dr Alcindor (12:36)
• Tyrosine Kinase Inhibitors (24:51)
• Gamma Secretase Inhibitors (31:02)
• Case: A woman...