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  2. HR-Positive Metastatic Breast Cancer — A Discussion and Debate on First- and Second-Line Therapy

HR-Positive Metastatic Breast Cancer — A Discussion and Debate on First- and Second-Line Therapy

Jun 11, 2026

Featuring perspectives from Dr Sara A Hurvitz and Dr Virginia Kaklamani, including the following topics:

  • Introduction: Which Biomarkers and When (0:00)
  • Optimizing First-Line Therapy for Patients with Hormone Receptor (HR)-Positive Metastatic Breast Cancer (mBC) (5:31)
  • SERENA-6 Trial (19:44)
  • Inavolisib (23:08)
  • Management of HR-Positive mBC Progressing on a CDK4/6 Inhibitor and Endocrine Therapy (31:46)
  • Selective Estrogen Receptor Degraders (41:15)
  • AKT (46:13)

CME information and select publications