Jan 9, 2020

Featuring one-on-one discussion with Dr Seth Pollack on the strategies employed by a panel of leading clinical investigators in a number of challenging clinical situations in the management of localized and metastatic soft tissue sarcoma, including the following topics:

• Initial Workup and Classification; Management of Localized Disease
• • Biopsy as part of the initial workup for localized soft tissue sarcoma (STS) (00:00)
  • Review of biopsy results by an expert pathologist or at a tertiary center of excellence; classification and incidence of STS (4:19)
  • Imaging studies for patients with undifferentiated pleomorphic sarcoma (UPS) (13:00)
  • Role of neoadjuvant therapy for patients with Grade 3 UPS (15:39)
  • Perspective on adjuvant therapy for patients with UPS (24:16)
  • Neoadjuvant therapy for Grade 1 leiomyosarcoma (29:21)
• Management of Metastatic Disease
• • Incidence and sites of oligometastatic disease; preference for biopsy and approach to surgical resection (32:16)
  • Sequencing therapies for a young patient with UPS; results from the Phase III ANNOUNCE trial of olaratumab for advanced STS (39:56)
  • Treatment algorithm for an elderly patient who presents with low-volume, asymptomatic, metastatic UPS (52:23)
  • Treatment approach for an elderly patient who presents with large-volume, symptomatic, metastatic UPS (54:21)
  • Sequencing therapies for a young patient with metastatic leiomyosarcoma; novel agents under investigation for STS (57:04)

CME information and select publications