Aug 31, 2023

Featuring perspectives from Dr Michael Wang, including the following topics:

• Algorithm for observation versus initiation of therapy for newly diagnosed mantle cell lymphoma (MCL) (0:00)
• First- and second-line therapy approaches for MCL (7:26)
• Case: A 45-year-old woman with relapsed MCL receiving acalabrutinib who develops severe headaches (10:21)
• Current role of ibrutinib in the treatment of MCL; use of single-agent venetoclax and of zanubrutinib in the treatment algorithm (14:59)
• Case: A 68-year-old man presenting with an enlarged spleen, no lymphadenopathy and a white blood cell count of 300,000 is diagnosed with MCL (17:48)
• Case: A 71-year-old man with multiregimen-relapsed, nodular type MCL presents with lymphadenopathy and a 3-cm tumor near the mediastinum (22:38)
• Patient selection for chimeric antigen receptor T-cell therapy (25:59)
• Novel and investigational therapeutic approaches for MCL (30:11)
• Treatment approaches for other histological variants of MCL (39:00)

CME information and select publications