Research To Practice | Oncology Videos: ER-Positive Metastatic Breast Cancer — An Interview with Prof Patrick Neven on the Role of Oral Selective Estrogen Receptor Degraders

ER-Positive Metastatic Breast Cancer — An Interview with Prof Patrick Neven on the Role of Oral Selective Estrogen Receptor Degraders

Nov 5, 2025

Featuring an interview with Prof Patrick Neven, including the following topics:

Emergence of ESR1 mutations in ER-positive, HER2-negative breast cancer (0:00)
Observed toxicity profile of oral selective estrogen receptor degraders (SERDs) (3:57)
Emerging data with novel oral SERD combinations (6:31)
Challenges for a general medical oncologist in breast cancer (8:41)
Sequencing and selection of therapies in ER-positive, HER2-negative breast cancer (12:16)
Evaluating the strategy of switching to an oral SERD during first-line endocrine therapy upon “molecular progression” (23:16)