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Jul 26, 2023

Featuring perspectives from Dr Carlos M de Castro, including the following topics:

  • Biology of paroxysmal nocturnal hemoglobinuria (PNH) (0:00)
  • Evolution of the PNH treatment landscape (13:07)
  • Selection and sequencing of therapies for patients with PNH (18:09)
  • Overview and presentation of extravascular hemolysis (23:50)
  • Case: A woman in her early 40s with PNH who developed Budd-Chiari syndrome and had an excellent response to C5 inhibition (26:57)
  • Case: A woman in her early 40s with a suboptimal response to ecluizumab followed by an excellent response to pegcetacoplan on the PEGASUS trial (34:00)
  • Case: A woman in her mid 40s who experienced breakthrough hemolysis with pegcetacoplan and was recently switched to iptacopan (38:40)

CME information and select publications