Multiple Myeloma Update — Part 4: Our interview with Dr Ghobrial
highlights the following topics as well as cases from her
practice:
Case: A woman in her late 60s with high-risk
R/R MM attains an excellent response to
daratumumab/pomalidomide/dexamethasone (00:00)
Evidence-based selection of up-front treatment combinations for
younger versus older patients with newly diagnosed MM (01:36)
Clinical significance of minimal residual disease (MRD)
assessment; correlation between MRD negativity and long-term
outcomes for patients with newly diagnosed MM receiving treatment
(05:08)
Selection, use and duration of maintenance therapy after ASCT
(08:26)
Significance of CHIP (clonal hematopoiesis of indeterminate
potential) mutations and increased predisposition to hematologic
cancer or cardiovascular-associated mortality (10:40)
Therapeutic options for patients who experience disease
progression on maintenance lenalidomide (13:52)
Mechanisms of action of elotuzumab and daratumumab; activity
and safety of immune-directed therapies for MM (15:47)
Response and tolerability of anti-BCMA CAR T-cell therapies
(18:25)
Case: A man in his mid-50s with
multiagent-refractory MM receives a BCMA-directed antibody-drug
conjugate on a clinical trial (21:46)
Case: A woman in her early 40s with high-risk
smoldering MM with deletion 17p experiences a partial response to
elotuzumab/lenalidomide/dexamethasone (24:26)
Efficacy and cardiotoxicity with second-line
carfilzomib/lenalidomide/dexamethasone followed by maintenance
carfilzomib/lenalidomide for del(17p) smoldering MM (27:50)
Activity of melflufen in patients with heavily pretreated MM
(29:56)
Newly approved and investigational approaches for heavily
pretreated MM (31:47)
Incidence of BRAF mutations in patients with MM; activity and
ongoing investigation of BRAF inhibitors for R/R MM (33:25)
Featuring the video recorded proceedings of events held in conjunction with important scientific symposia, live webcasts and closed meetings featuring the perspectives of renowned clinical investigators, these videos provide an overview of important advances in the management of a number of solid tumors and hematologic cancers.