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Feb 5, 2021

Melanoma Update, Issue 1, 2021 — Part 1: Our interview with Dr Davies highlights the following topics as well as cases from his practice:

  • Evolving treatment approaches for regionally metastatic melanoma (0:00)
  • Case: A man in his early 70s with a history of poorly controlled hypertension who is diagnosed with Stage IIIB melanoma with a BRAF V600E mutation (20:42)
  • Case: A woman in her mid-20s with Stage IIIA melanoma with a BRAF V600E mutation (28:46)
  • Case: A man in his early 30s with Stage IIIC melanoma and an NRAS Q61K mutation (37:53)
  • Role of immunotherapy for patients with melanoma in the adjuvant setting (44:16)
  • Adjuvant therapy with BRAF/MEK inhibitors for patients with melanoma and BRAF mutations (48:51)
  • Design and results of the Phase III KEYNOTE-054 trial comparing pembrolizumab to placebo after complete resection of high-risk Stage III melanoma (50:58)
  • Benefits and risks of adjuvant immunotherapy and targeted therapy (53:06)
  • Risk of brain metastases for patients with melanoma; efficacy of nivolumab/ipilimumab in patients with brain metastases (57:16)
  • Activity and tolerability of dabrafenib/trametinib as adjuvant therapy (1:01:38)
  • Emerging data with targeted therapy and immunotherapy in the neoadjuvant setting (1:08:45)
  • Role of immunotherapy and targeted therapy for mucosal and uveal melanoma; improvement in overall survival with the novel bispecific fusion protein tebentafusp for metastatic uveal melanoma (1:13:57)
  • Efficacy of autologous tumor infiltrating lymphocytes (TILs) for patients with metastatic melanoma (1:16:54)
  • Approach to relapse after immunotherapy or targeted therapy in the adjuvant setting (1:19:43)
  • Emerging data from the Phase III CheckMate 915 trial of nivolumab alone or with ipilimumab for patients with resected high-risk melanoma; results of the CheckMate 067 trial of nivolumab or ipilimumab alone or in combination for advanced melanoma (1:23:15)

CME information and select publications