Jul 12, 2019

A presentation from Dr O’Shaughnessy featuring emerging research and cases from her practice.

• Introduction (00:00)
• • Program overview: Dr Love
• Estrogen and Progesterone Receptors; Clinical Use of Endocrine Treatment (1:20)
• Case: A woman in her early 60s with ER/PR-positive, HER2-negative breast cancer (BC) who experienced intolerable arthralgias with adjuvant aromatase inhibition and was switched to tamoxifen (7:08)
• First-Line Endocrine Therapy for Metastatic Disease: Role of CDK4/6 Inhibitors (12:44)
• Case: A woman in her mid-60s with ER/PR-positive de novo metastatic BC (mBC) who received palbociclib/letrozole (12:54)
• Case: A woman in her mid-50s with ER/PR-positive, HER2-negative BC who developed metastatic disease after receiving 4 years of adjuvant letrozole and started treatment with ribociclib/fulvestrant (27:39)
• Case: A woman in her early 60s who received abemaciclib/exemestane for ER/PR-positive, HER2-negative mBC to the brain and bone (33:09)
• Second-Line Endocrine Therapy for Metastatic Disease: Role of mTOR Inhibitors (42:18)
• Case: A woman in her late 60s with ER/PR-positive, HER2-negative mBC who received exemestane/everolimus after disease progression on a CDK4/6 inhibitor (42:26)
• New Approaches Under Investigation (51:47)
• Assessing and Optimizing Treatment Adherence (59:00)
• Case: A woman in her early 30s with ER/PR-positive, HER2-negative BC who demonstrated poor adherence to adjuvant endocrine therapy because of weight gain (59:09)

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